PF-07247685
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| HY-155157-5MG | 5 mg | 495,00 | Add | |
| HY-155157-10MG | 10 mg | 786,00 | Add | |
| HY-155157-25MG | 25 mg | 1'558,00 | Add | |
| HY-155157-50MG | 50 mg | 2'489,00 | Add | |
| HY-155157-100MG | 100 mg | 3'979,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
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PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC50=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice[1].
| Category | Biochemicals |
| Supplier | MedChem Express |
| Regulatory Status | RUO |
| Research Field | Cardiovascular Disease, Metabolic Enzyme/Protease |
| Format | Solubility: DMSO : 100 mg/mL (ultrasonic) |
| Grade | Clinical information: No Development Reported |
| Purity | 99.57% |
| Molecular Formula | C21H20N2O3S |
| Molecular Weight | 380.46 |
| Storage Conditions | -20°C, 3 years; 4°C, 2 years (Powder) |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | http://www.medchemexpress.com |
| Shipping Details | Room Temperature |
| Material Safety Data Sheet | Download PDF |
