ADS032
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| HY-156798-5MG | 5 mg | 165,00 | Add | |
| HY-156798-1ML | 10mM/1mL | 181,00 | Add | |
| HY-156798-10MG | 10 mg | 274,00 | Add | |
| HY-156798-25MG | 25 mg | 532,00 | Add | |
| HY-156798-50MG | 50 mg | 901,00 | Add | |
| HY-156798-100MG | 100 mg | 1'432,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
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ADS032 is a dual inhibitor of NLRP1 and NLRP3 that can rapidly, reversibly and stably inhibit inflammasome formation. ADS032 can reduce NLPR1 and NLRP3 activation of human macrophages and bronchial epithelial cells to secrete and mature IL-1β and TNF-α, and reduce NLRP3-induced ASC speck formation. ADS032 protected mice against the deadly influenza A virus, reducing inflammation in the lungs and improving survival. ADS032 inhibits Nigericin (HY-127019)-induced IL-1β secretion with IC50s of 94.6 μM (No wash out) and 354 μM (Wash out) respectively[1].
| Category | Biochemicals |
| Supplier | MedChem Express |
| Regulatory Status | RUO |
| Research Field | Inflammation/Immunology, Immunology/Inflammation |
| Format | Solubility: DMSO : 100 mg/mL (ultrasonic) |
| Grade | Clinical information: No Development Reported |
| Purity | 99.74% |
| Molecular Formula | C22H29NO4S |
| Molecular Weight | 403.53 |
| CAS-Number | 2757333-37-0 |
| Storage Conditions | -20°C, 3 years; 4°C, 2 years (Powder) |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | http://www.medchemexpress.com |
| Shipping Details | Room Temperature |
| Material Safety Data Sheet | Download PDF |
