In Vivo Grade Recombinant Anti-mouse PD-1 / VEGF-A Bispecific Antibody, Mouse IgG2c LALAPG Kappa ...

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Product Description

In Vivo Grade Recombinant Anti-mouse PD-1 / VEGF-A Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone RMP1-14.1 / B20-4.1.1.1)
The rat anti-mouse PD-1 monoclonal antibody (clone No. RMP1-14, rat IgG2a kappa) reacts with the mouse PD-1 protein (CD279 or programmed death-1) encoded by the mouse pdcd1 gene, a member of the CD28 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2, both of which belong to the B7 family. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD 1 antibody and the anti-mouse PD L1 antibody which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The RMP1-14 antibody blocks the binding of both the mouse PD-L1 protein and the mouse PD-L2 protein to the mouse PD-1 protein.It is under investigation how the recombinant anti-mouse PD-1 / VEGF-A bispecific antibodies (RMP1-14.1 / B20-4.1.1.1) behave different from the individual monoclonal antibodies and their combination.Our recombinant anti-mouse PD-1 / VEGF-A bispecific antibodies have a part (variable regions) or complete amino acid sequences of the rat anti-mouse PD-1 antibody (hybridoma clone name or number: RMP1-14) and the mouse anti-mouse VEGF-A antibody (hybridoma